Steve Morrow breaking his collarbone celebrating Arsenal's 1993 League Cup win, Ever Banega injuring his ankle after being run over by his own car and Jerome Boateng aggravating a knee complaint in a collision with an airline drinks trolley.
There certainly hasn't been a shortage of freak injuries involving footballers over the years.
Santiago was another name to suffer similar misfortune, albeit at the worst possible time of his career.
Canizares, then 32, had just established himself as Spain's No. 1 heading into the 2002 World Cup before disaster struck in his hotel room - yes, you heard right.
The former Real Madrid and Valencia goalkeeper managed to severe a tendon in his right foot after he accidentally smashed a bottle of aftershave in the sink, with a shard of glass subsequently landing on the floor and penetrating his flesh.
Canizares was taken to Jerez general hospital where he underwent surgery, and managed to put on a brave face to reporters having being told shortly afterwards that his tournament was over before it had even started.
"I do not consider myself to be unlucky by any means," he told reporters at the club's training base. "From the start of my career I have had several strokes of good luck.
"But, just like everyone else, I have also had difficult times which I have had to cope with. Now I have to overcome this blow to my morale, and in my case that may take a week or just three days.
"No-one makes their way in the world of football without having to overcome obstacles.
"I still believe that the best moments of my career are yet to come and, health permitting, I will be aiming to be successful in the next World Cup."
Gaizka Mendieta, who was part of the Spain squad at that time, recalled to talkSPORT about how the freak episode unfolded.
"We were just shocked. We just heard this noise when we were in our bedrooms. We weren't allowed to go in the room because there was glass everywhere," the former Middlesbrough midfielder told Kick Off.
"We went to Santiago Canizares' room but they [the doctors] said to us 'no, no, don't come in, it's bad'.
"We found out later what happened and the fact that he was out of the team because of that was devastating."
Spain suffered a shock quarter-final exit at that tournament at the hands of surprise package South Korea, losing 5-3 on penalties after the contest finished goalless after 120 minutes.
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